Semi-solid extrusion 3D printing in drug delivery and biomedicine: Personalised solutions for healthcare challenges

Written by Patricija Januskaite.

A broad-spectrum additive manufacturing technology, 3D printing (3DP) is comprised of several different technologies, with only a select few being currently utilised in the pharmaceutical field. Semi-solid extrusion (SSE) is a material extrusion-based technique, able to construct a 3D object via the sequential deposition of a gel or paste. The unique features offered by SSE 3DP such as the feedstock materials used, low printing temperatures and disposable syringes, make it especially applicable for bioprinting and pharmaceutical applications.

In our recent review, we highlight the key printing process parameters that have a direct affect on the final product properties: extrusion mechanism, nozzle diameter, travel speed and extrusion rate, printing temperature, printer calibration, and material properties to name a few. This is followed by a detailed overview and discussion of the most recent advances in drug development, bioprinting and bioelectronics using SSE 3DP. The review also explores the various advantages and healthcare applications of the technology, highlighting its future potential in the personalisation of medicines.

To read the full review click here: https://doi.org/10.1016/j.jconrel.2021.02.027