Advances in Colon-Targeted Drug Delivery Technologies

Targeted drug delivery to the colon is revolutionizing treatment for inflammatory bowel disease (IBD) and beyond. In this review, we explore cutting-edge oral technologies that leverage the colon’s unique environment—its pH levels, microbiota, and transit time—for precise therapeutic release. Traditional approaches like pH- and microbiota-responsive coatings have shown promise but often fail due to physiological variability. Newer multi-trigger systems, such as Phloral® and OPTICORE™, combine multiple release mechanisms, greatly improving reliability and efficacy.

The review also highlights the potential for these technologies to enable oral delivery of biologics—an exciting step forward considering current treatments require injections. Platforms like MB-001 and advanced nanoparticle systems are pushing these boundaries. Meanwhile, 3D printing offers a game-changing level of personalization, allowing for patient-specific dosage forms that could enhance treatment outcomes. Though challenges like scalability and clinical translatability are highlighted here, these innovations mark a major leap forward. With continued research and development, colon-targeted drug delivery could soon offer more effective, convenient, and personalized treatments for a wide range of diseases.

Check out our article published in Current Opinion in Gastroenterology here!